Identification of biological processes regulated by the transcription
factor RUNX1: implication for leukemia and thrombocytopenia
development
Table II
Probe.Set.ID E8.5 M E8.5 t E12 M E12 t UniGene ID Gene Title Gene Symbol 1415670_at -0.357 -1.134 -2.52E-01 -7.98E-01 Mm.258785 "coatomer protein complex, subunit gamma" Copg 1415671_at -0.328 -1.108 -1.67E-01 -5.63E-01 Mm.17708 "ATPase, H+ transporting, V0 subunit D isoform 1" Atp6v0d1 1415672_at 0.440 0.679 1.44E-01 2.21E-01 Mm.196269 "golgi autoantigen, golgin subfamily a, 7" Golga7 1415673_at -0.097 -0.581 5.49E-02 3.28E-01 Mm.271784 phosphoserine phosphatase Psph 1415674_a_at -0.007 -0.029 7.62E-02 3.30E-01 Mm.29814 trafficking protein particle complex 4 Trappc4 1415675_at -0.028 -0.138 9.84E-02 4.88E-01 Mm.22001 dolichol-phosphate (beta-D) mannosyltransferase 2 Dpm2 1415676_a_at -0.148 -0.403 -1.70E-01 -4.64E-01 Mm.8911 "proteasome (prosome, macropain) subunit, beta type 5" Psmb5 1415677_at -0.022 -0.044 -1.52E-01 -3.06E-01 Mm.21623 dehydrogenase/reductase (SDR family) member 1 Dhrs1 1415678_at 0.321 1.390 2.26E-02 9.77E-02 Mm.261045 "protein phosphatase 1A, magnesium dependent, alpha isoform" Ppm1a 1415679_at 0.167 0.640 5.66E-02 2.17E-01 Mm.309736 presenilin enhancer 2 homolog (C. elegans) Psenen 1415680_at -0.142 -0.425 5.89E-02 1.76E-01 Mm.277408 anaphase promoting complex subunit 1 Anapc1 1415681_at -0.102 -0.385 -6.23E-02 -2.36E-01 Mm.44174 mitochondrial ribosomal protein L43 Mrpl43 1415682_at 0.108 0.267 -1.62E-01 -3.99E-01 Mm.152987 exportin 7 Xpo7 1415683_at -0.177 -1.153 -3.48E-01 -2.27E+00 Mm.10265 N-myristoyltransferase 1 Nmt1 1415684_at 0.324 0.606 2.35E-01 4.40E-01 Mm.22264 autophagy 5-like (S. cerevisiae) Apg5l 1415685_at 0.042 0.108 3.86E-01 1.01E+00 Mm.285429 mitochondrial translational initiation factor 2 Mtif2 1415686_at 0.043 0.082 1.66E-01 3.17E-01 Mm.198264 "RAB14, member RAS oncogene family" Rab14 1415687_a_at -0.676 -0.846 -2.32E-01 -2.90E-01 Mm.277498 prosaposin Psap 1415688_at 0.649 2.019 3.24E-01 1.01E+00 Mm.340315 "ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, C. elegans)" Ube2g1 1415689_s_at 0.399 1.012 1.84E-01 4.68E-01 Mm.296071 zinc finger protein 307 Zfp307 1415690_at 0.182 0.764 4.91E-02 2.06E-01 Mm.34951 mitochondrial ribosomal protein L27 Mrpl27 1415691_at 0.157 0.554 1.78E-01 6.29E-01 Mm.382 "discs, large homolog 1 (Drosophila)" Dlgh1 1415692_s_at 0.066 0.172 -3.93E-02 -1.03E-01 Mm.248827 calnexin Canx 1415693_at -0.388 -0.555 -2.06E-01 -2.94E-01 Mm.289387 "Der1-like domain family, member 1" Derl1 1415694_at 0.137 0.252 -2.28E-02 -4.19E-02 --- --- --- 1415695_at 0.431 0.971 2.64E-01 5.95E-01 Mm.121265 "proteasome (prosome, macropain) subunit, alpha type 1" Psma1 1415696_at -0.005 -0.010 1.57E-01 3.17E-01 Mm.6698 SAR1a gene homolog 1 (S. cerevisiae) Sara1 1415697_at 0.328 1.251 2.81E-01 1.07E+00 Mm.290530 RIKEN cDNA E430034L04 gene E430034L04Rik 1415698_at -0.166 -0.380 3.59E-01 8.20E-01 Mm.171335 golgi phosphoprotein 2 Golph2 1415699_a_at -0.202 -0.957 2.03E-01 9.64E-01 Mm.30195 G protein pathway suppressor 1 Gps1 1415700_a_at 0.759 1.243 3.16E-01 5.17E-01 Mm.232728 "signal sequence receptor, gamma" Ssr3 1415701_x_at -0.034 -0.140 1.63E-01 6.62E-01 Mm.140380 ribosomal protein L23 Rpl23 1415702_a_at 0.270 1.386 -2.18E-01 -1.12E+00 Mm.7286 C-terminal binding protein 1 Ctbp1 1415703_at -0.478 -1.383 -2.35E-01 -6.81E-01 Mm.27372 "HECT, UBA and WWE domain containing 1" Huwe1 1415704_a_at -0.147 -0.426 1.66E-01 4.83E-01 Mm.261025 carnitine deficiency-associated gene expressed in ventricle 3 Cdv3 1415705_at 0.059 0.084 1.31E-01 1.86E-01 Mm.22565 RIKEN cDNA 9130011J15 gene 9130011J15Rik 1415706_at 0.032 0.171 -3.35E-02 -1.76E-01 Mm.30041 coatomer protein complex subunit alpha Copa 1415707_at -0.266 -1.109 -1.04E-01 -4.34E-01 Mm.291624 anaphase promoting complex subunit 2 Anapc2 1415708_at 0.463 1.149 6.51E-01 1.61E+00 Mm.359796 expressed sequence AI316828 AI316828 1415709_s_at -0.049 -0.209 -1.00E-01 -4.27E-01 Mm.271620 golgi-specific brefeldin A-resistance factor 1 Gbf1 1415710_at -0.055 -0.172 -5.10E-01 -1.58E+00 Mm.319697 cDNA sequence BC038311 BC038311 1415711_at -0.128 -0.227 3.69E-01 6.54E-01 Mm.229141 ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) Arfgef1 1415712_at 0.362 0.445 -5.86E-02 -7.20E-02 Mm.246240 "zinc finger, RAN-binding domain containing 1" Zranb1 1415713_a_at -0.102 -0.569 -7.66E-02 -4.25E-01 Mm.3935 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 Ddx24 1415714_a_at -0.104 -0.231 1.84E-01 4.06E-01 Mm.182650 RIKEN cDNA 2610209M04 gene 2610209M04Rik 1415715_at 0.040 0.154 -1.53E-01 -5.89E-01 Mm.332317 RIKEN cDNA 2410015J15 gene 2410015J15Rik 1415716_a_at -0.026 -0.049 -5.81E-02 -1.09E-01 Mm.270283 ribosomal protein S27 Rps27 1415717_at -0.122 -0.528 -1.52E-01 -6.57E-01 Mm.318331 RIKEN cDNA 4931406I20 gene 4931406I20Rik 1415718_at -0.846 -2.717 -3.22E-01 -1.03E+00 Mm.340083 RIKEN cDNA 2310079P12 gene 2310079P12Rik 1415719_s_at 0.403 1.254 3.60E-01 1.12E+00 Mm.200383 armadillo repeat containing 1 Armc1 1415720_s_at -0.044 -0.159 -1.84E-01 -6.61E-01 Mm.272024 MAD2L1 binding protein Mad2l1bp 1415721_a_at -0.105 -0.591 -8.74E-02 -4.93E-01 Mm.133257 RIKEN cDNA 1200013P24 gene 1200013P24Rik 1415722_a_at 0.200 0.735 3.63E-01 1.33E+00 Mm.227983 RIKEN cDNA 1110059P08 gene 1110059P08Rik 1415723_at 0.064 0.184 2.02E-01 5.80E-01 Mm.271222 eukaryotic translation initiation factor 5 Eif5 1415724_a_at 0.294 0.452 1.29E-01 1.99E-01 Mm.1022 cell division cycle 42 homolog (S. cerevisiae) Cdc42 1415725_at 0.279 0.954 -1.56E-01 -5.34E-01 Mm.288606 RRN3 RNA polymerase I transcription factor homolog (yeast) Rrn3 1415726_at -0.254 -1.536 2.10E-01 1.27E+00 Mm.245522 ankyrin repeat domain 17 Ankrd17 1415727_at -0.064 -0.144 -2.27E-01 -5.13E-01 Mm.205996 apolipoprotein A-I binding protein Apoa1bp 1415728_at -0.055 -0.141 -2.91E-01 -7.53E-01 Mm.7723 "poly(A) binding protein, nuclear 1" Pabpn1 1415729_at -0.252 -0.666 -2.33E-01 -6.16E-01 Mm.10504 3-phosphoinositide dependent protein kinase-1 Pdpk1 1415730_at 0.028 0.058 1.33E-02 2.82E-02 Mm.293980 RIKEN cDNA 5730453I16 gene 5730453I16Rik 1415731_at -0.009 -0.038 1.25E-01 5.29E-01 Mm.289914 "DNA segment, Chr 1, ERATO Doi 396, expressed" D1Ertd396e 1415732_at 0.013 0.061 -1.98E-01 -9.10E-01 Mm.43745 HLA-B associated transcript 5 Bat5 1415733_a_at 0.215 0.723 -1.30E-01 -4.37E-01 Mm.282081 RIKEN cDNA 1110019J04 gene 1110019J04Rik 1415734_at 0.602 2.344 -2.62E-02 -1.02E-01 Mm.333233 "RAB7, member RAS oncogene family" Rab7 1415735_at -0.131 -0.334 -1.07E-01 -2.71E-01 Mm.289915 damage specific DNA binding protein 1 Ddb1 1415736_at -0.117 -0.207 1.33E-01 2.37E-01 Mm.158264 prefoldin 5 Pfdn5 1415737_at 0.333 1.067 -2.24E-01 -7.16E-01 Mm.7013 riboflavin kinase Rfk 1415738_at 0.649 1.372 2.98E-01 6.29E-01 Mm.159965 RIKEN cDNA 0610040B21 gene 0610040B21Rik 1415739_at -0.383 -1.235 -3.30E-01 -1.07E+00 Mm.306805 RIKEN cDNA 3100004P22 gene 3100004P22Rik 1415740_at 0.135 0.366 -3.66E-01 -9.94E-01 Mm.272361 "protease (prosome, macropain) 26S subunit, ATPase 5" Psmc5 1415741_at 0.211 0.780 2.08E-01 7.67E-01 Mm.790 TPA regulated locus Tparl 1415742_at -0.346 -1.767 -3.88E-01 -1.98E+00 Mm.275961 ancient ubiquitous protein Aup1 1415743_at 0.020 0.054 -3.35E-01 -9.00E-01 Mm.22665 histone deacetylase 5 Hdac5 1415744_at -0.335 -0.894 -1.98E-01 -5.30E-01 --- --- --- 1415745_a_at 0.184 1.028 1.37E-01 7.67E-01 Mm.7472 Down syndrome critical region gene 3 Dscr3 1415746_at -0.264 -0.809 -4.06E-02 -1.25E-01 Mm.28833 capicua homolog (Drosophila) Cic 1415747_s_at 0.357 1.070 3.05E-01 9.15E-01 Mm.28551 RIO kinase 3 (yeast) Riok3 1415748_a_at -0.137 -0.283 5.33E-02 1.10E-01 Mm.27270 dynactin 5 Dctn5 1415749_a_at 0.066 0.183 6.56E-02 1.81E-01 Mm.220922 Ras-related GTP binding C Rragc 1415750_at -0.204 -0.965 -2.38E-01 -1.12E+00 Mm.100353 transducin (beta)-like 3 Tbl3 1415751_at 0.236 1.468 -2.10E-01 -1.31E+00 Mm.354643 "heterochromatin protein 1, binding protein 3" Hp1bp3 1415752_at -0.001 -0.003 2.56E-01 9.19E-01 Mm.29866 cDNA sequence BC031181 BC031181 1415753_at 0.103 0.594 -1.34E-01 -7.76E-01 Mm.29802 "DNA segment, Chr 10, Brigham & Women's Genetics 1364 expressed" D10Bwg1364e 1415754_at -0.236 -1.219 -3.42E-01 -1.77E+00 Mm.279861 RIKEN cDNA 1810060D16 gene 1810060D16Rik 1415755_a_at -0.083 -0.189 -4.80E-01 -1.10E+00 Mm.278783 ubiquitin-conjugating enzyme E2 variant 1 Ube2v1 1415756_a_at -0.020 -0.073 2.37E-01 8.59E-01 Mm.331182 SNAP-associated protein Snapap 1415757_at 0.055 0.190 2.81E-03 9.75E-03 Mm.271620 golgi-specific brefeldin A-resistance factor 1 Gbf1 1415758_at -0.243 -0.611 -2.26E-01 -5.67E-01 --- RIKEN cDNA 2010313D22 gene 2010313D22Rik 1415759_a_at 0.347 1.635 3.06E-01 1.44E+00 Mm.290035 hepatitis B virus x interacting protein Hbxip 1415760_s_at -0.168 -0.707 -1.82E-01 -7.69E-01 Mm.217759 ATX1 (antioxidant protein 1) homolog 1 (yeast) Atox1 1415761_at -0.056 -0.105 -2.39E-01 -4.46E-01 Mm.248163 mitochondrial ribosomal protein L52 Mrpl52 1415762_x_at 0.002 0.003 -2.83E-01 -5.19E-01 Mm.248163 mitochondrial ribosomal protein L52 Mrpl52 1415763_a_at -0.064 -0.156 -2.36E-01 -5.80E-01 --- --- --- 1415764_at -0.151 -0.557 1.70E-01 6.30E-01 Mm.245357 RIKEN cDNA 5730454B08 gene 5730454B08Rik 1415765_at -0.223 -0.932 -4.53E-01 -1.89E+00 Mm.347805 RIKEN cDNA 1110031M08 gene /// similar to hypothetical protein 1110031M08Rik /// LOC381212 1415766_at -0.059 -0.229 -2.07E-02 -8.07E-02 --- RIKEN cDNA 4930564D15 gene 4930564D15Rik 1415767_at 0.200 0.316 -4.02E-02 -6.36E-02 Mm.30205 YTH domain family 1 Ythdf1 1415768_a_at 0.022 0.040 -8.89E-03 -1.65E-02 Mm.207678 ubiquitin-conjugating enzyme E2R 2 Ube2r2 1415769_at 0.275 1.419 1.58E-01 8.17E-01 Mm.208286 itchy Itch 1415770_at -0.174 -0.613 4.58E-03 1.61E-02 Mm.335454 WD repeat domain 6 Wdr6 1415771_at 0.154 0.318 3.22E-01 6.63E-01 Mm.154378 nucleolin Ncl 1415772_at -0.085 -0.193 1.75E-01 3.98E-01 Mm.154378 nucleolin Ncl 1415773_at -0.484 -0.909 1.37E-01 2.57E-01 Mm.154378 nucleolin Ncl 1415774_at -0.214 -0.822 2.64E-01 1.02E+00 Mm.25298 signal transducer and activator of transcription interacting protein 1 Statip1 1415775_at -0.002 -0.007 4.18E-02 1.20E-01 Mm.270186 retinoblastoma binding protein 7 Rbbp7 1415776_at 0.181 0.968 -1.40E-01 -7.48E-01 --- --- --- 1415777_at 0.321 1.570 -1.76E-01 -8.61E-01 Mm.10753 pancreatic lipase related protein 1 Pnliprp1 1415778_at 0.170 0.399 2.82E-01 6.63E-01 Mm.27218 mortality factor 4 like 2 Morf4l2 1415779_s_at -0.075 -0.246 7.75E-02 2.54E-01 Mm.196173 "actin, gamma, cytoplasmic 1" Actg1 1415780_a_at 1.511 2.423 1.41E-02 2.27E-02 Mm.285969 "armadillo repeat containing, X-linked 2" Armcx2 1415781_a_at 0.152 0.498 1.43E-01 4.68E-01 Mm.29923 SMT3 suppressor of mif two 3 homolog 2 (yeast) Sumo2 1415782_at 0.350 0.959 4.07E-01 1.12E+00 Mm.29923 SMT3 suppressor of mif two 3 homolog 2 (yeast) Sumo2 1415783_at 0.577 1.430 6.78E-01 1.68E+00 Mm.296520 vacuolar protein sorting 35 Vps35 1415784_at -0.075 -0.350 3.13E-02 1.45E-01 Mm.296520 vacuolar protein sorting 35 Vps35 1415785_a_at 0.003 0.008 1.93E-01 5.23E-01 Mm.328673 chaperonin subunit 8 (theta) Cct8 1415786_at 0.097 0.415 2.35E-01 1.01E+00 Mm.22957 progastricsin (pepsinogen C) Pgc 1415787_at -0.158 -0.618 1.59E-02 6.22E-02 Mm.3196 alpha glucosidase 2 alpha neutral subunit Ganab 1415788_at 0.779 2.033 7.18E-01 1.87E+00 --- --- --- 1415789_a_at 0.168 0.549 5.11E-01 1.67E+00 Mm.338784 cDNA sequence BC002236 BC002236 1415790_at 0.188 0.644 2.83E-01 9.71E-01 Mm.338784 cDNA sequence BC002236 BC002236 1415791_at 0.473 2.410 2.26E-01 1.15E+00 Mm.236449 ring finger protein 34 Rnf34 1415792_at -0.181 -1.170 -3.35E-01 -2.16E+00 Mm.182145 expressed sequence AL033326 AL033326 1415793_at -0.628 -2.148 -7.61E-01 -2.61E+00 Mm.254704 pyridoxine 5'-phosphate oxidase Pnpo 1415794_a_at 0.328 1.087 4.07E-02 1.35E-01 Mm.188432 spindlin Spin 1415795_at 0.059 0.196 1.68E-02 5.60E-02 Mm.188432 spindlin Spin 1415796_at 0.262 0.639 -4.78E-02 -1.17E-01 Mm.292530 DAZ associated protein 2 Dazap2 1415797_at -0.258 -0.678 -1.95E-01 -5.12E-01 Mm.5021 "discoidin domain receptor family, member 1" Ddr1 1415798_at -0.080 -0.367 -5.67E-03 -2.59E-02 Mm.5021 "discoidin domain receptor family, member 1" Ddr1 1415799_at -0.276 -1.145 -5.72E-01 -2.37E+00 Mm.141197 WW domain binding protein 11 Wbp11 1415800_at 0.955 2.600 3.03E-02 8.26E-02 Mm.370184 gap junction membrane channel protein alpha 1 Gja1 1415801_at 0.300 0.722 -8.02E-02 -1.93E-01 Mm.370184 gap junction membrane channel protein alpha 1 Gja1 1415802_at 0.311 0.787 -1.20E-01 -3.04E-01 Mm.9086 "solute carrier family 16 (monocarboxylic acid transporters), member 1" Slc16a1 1415803_at -0.012 -0.065 -2.79E-01 -1.54E+00 Mm.103711 chemokine (C-X3-C motif) ligand 1 Cx3cl1 1415804_at 0.344 1.470 8.64E-02 3.69E-01 Mm.103711 chemokine (C-X3-C motif) ligand 1 Cx3cl1 1415805_at -0.349 -1.350 8.04E-03 3.11E-02 Mm.21160 "colipase, pancreatic" Clps 1415806_at -0.058 -0.093 -1.18E-01 -1.90E-01 --- --- --- 1415807_s_at -0.092 -0.381 -2.93E-01 -1.21E+00 Mm.370205 "splicing factor, arginine/serine-rich 2 (SC-35)" Sfrs2 1415808_at -2.612 -1.749 -4.34E-02 -2.91E-02 Mm.2372 trophoblast specific protein alpha Tpbpa 1415809_at -0.430 -0.982 6.98E-02 1.59E-01 Mm.2372 trophoblast specific protein alpha Tpbpa 1415810_at -0.639 -2.405 -2.13E-01 -8.03E-01 Mm.42196 "ubiquitin-like, containing PHD and RING finger domains, 1" Uhrf1 1415811_at -0.028 -0.062 -2.34E-01 -5.26E-01 Mm.42196 "ubiquitin-like, containing PHD and RING finger domains, 1" Uhrf1 1415812_at -2.370 -2.761 -5.31E-01 -6.18E-01 Mm.21109 gelsolin Gsn 1415813_at 0.331 1.148 2.09E-01 7.26E-01 --- --- --- 1415814_at 0.071 0.163 -2.88E-02 -6.63E-02 Mm.249096 "ATPase, H+ transporting, V1 subunit B, isoform 2" Atp6v1b2 1415815_at -0.451 -2.674 1.77E-02 1.05E-01 --- --- --- 1415816_at -0.093 -0.266 2.68E-02 7.70E-02 Mm.289900 chaperonin subunit 7 (eta) Cct7 1415817_s_at -0.258 -0.594 5.25E-02 1.21E-01 Mm.289900 chaperonin subunit 7 (eta) Cct7 1415818_at 0.316 1.162