Identification of biological processes regulated by the transcription
factor RUNX1: implication for leukemia and thrombocytopenia
development
Table I
Acc UGCluster Name Symbol FPD FPD M FPD t CBF CBF M CBF t TELRUNX1 TELRUNX1 M TELRUNX1 t Refseq CUREOS Human Gene ID mouse Affymetrix probes E8.5 M 8.5 t 8.5 E12 M 12 t 12 mouse Unigene Mouse Gene Symbol AA001219 Hs.527973 Suppressor of cytokine signaling 3 SOCS3 0 -0.02 -0.4 0 0.01 0.2 0 -0.1 -1.4 NM_003955 1 9021 1416576_at -1 -0.3 -1.193 0 2.74E-01 1.09E+00 Mm.3468 Socs3 1455899_x_at -1.715 -2.492 -2.25E-01 -3.28E-01 Mm.3468 Socs3 1456212_x_at -1.397 -1.784 -1.10E-01 -1.41E-01 Mm.3468 Socs3 AA001376 Hs.157883 Zinc finger protein 187 ZNF187 0 0.04 0.5 0 0.06 0.9 0 0 0 NM_152736 ND 7741 1457285_at 0 0.021 0.037 0 4.06E-01 7.16E-01 Mm.235360 AA001403 Hs.132642 "Zinc metallopeptidase (STE24 homolog, yeast)" ZMPSTE24 0 0.09 1.3 0 0.06 1.4 1 0.21 3.2 NM_005857 0 10269 1427923_at 0 0.088 0.282 0 5.09E-01 1.63E+00 Mm.34399 Zmpste24 AA001432 Hs.436367 "Laminin, alpha 3" LAMA3 0 0.16 1.4 0 -0.02 -0.4 0 -0.09 -1.4 NM_000227 0 3909 1427512_a_at 0 0.23 0.854 0 -1.76E-01 -6.53E-01 Mm.42012 Lama3 1444860_at -0.077 -0.367 1.40E-02 6.65E-02 Mm.42012 Lama3 AA001444 Hs.526754 "Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)" MEIS1 0 0.13 1.1 1 0.2 3.9 1 0.18 2.6 NM_002398 1 4211 Data not found ND ND AA001449 Hs.371249 "Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" PTN 0 -0.03 -0.3 0 0.08 0.8 0 0.14 0.9 NM_002825 1 5764 1416211_a_at 0 1.168 0.926 0 3.72E-01 2.95E-01 Mm.279690 Ptn 1443173_at 0.094 0.244 3.27E-01 8.53E-01 Mm.279690 Ptn 1443809_at -0.057 -0.316 2.63E-02 1.47E-01 Mm.279690 Ptn 1448254_at 2.288 1.509 2.09E-01 1.38E-01 Mm.279690 Ptn AA001449 Hs.371249 "Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" PTN 0 0.18 2.4 0 0.01 0.1 0 -0.09 -0.9 NM_002825 1 5764 1416211_a_at 0 1.168 0.926 0 3.72E-01 2.95E-01 Mm.279690 Ptn 1443173_at 0.094 0.244 3.27E-01 8.53E-01 Mm.279690 Ptn 1443809_at -0.057 -0.316 2.63E-02 1.47E-01 Mm.279690 Ptn 1448254_at 2.288 1.509 2.09E-01 1.38E-01 Mm.279690 Ptn AA001614 Data not found 0 0.22 2.7 0 0.04 0.6 0 0.21 2 ND Data not found AA001745 Hs.445803 DC2 protein DC2 -1 -0.28 -5.4 0 0.06 2.1 0 0.05 1.1 NM_021227 0 58505 1429898_at 0 -0.276 -0.869 0 -3.44E-02 -1.08E-01 Mm.300697 2310008M10Rik 1449139_at 0.442 1.003 3.32E-01 7.53E-01 Mm.300697 2310008M10Rik AA001749 Hs.472437 "Microtubule-associated protein, RP/EB family, member 1" MAPRE1 0 0.14 2.3 -1 -0.16 -3.4 0 -0.08 -1 NM_012325 1 22919 1422764_at 1 0.111 0.334 0 2.55E-01 7.67E-01 Mm.143877 Mapre1 1422765_at 0.835 4.955 2.49E-01 1.48E+00 Mm.143877 Mapre1 1428819_at 0.426 0.84 7.31E-02 1.44E-01 Mm.143877 Mapre1 1428820_at -0.189 -0.57 -1.53E-01 -4.60E-01 Mm.143877 Mapre1 1450740_a_at 0.25 0.597 2.89E-01 6.90E-01 Mm.143877 Mapre1 AA001897 Hs.119825 "Spectrin, alpha, erythrocytic 1 (elliptocytosis 2)" SPTA1 0 0.07 0.7 1 0.21 4.1 0 -0.13 -1.6 NM_003126 0 6708 1421277_at 0 -1.176 -1.64 0 -8.59E-02 -1.20E-01 Mm.200611 Spna1 1421278_s_at -1.343 -1.699 -1.37E-01 -1.74E-01 Mm.200611 Spna1 AA002086 Hs.1311 "CD1C antigen, c polypeptide" CD1C 0 0.29 3.4 0 -0.01 -0.1 0 -0.06 -0.7 NM_001765 ND 911 Data not found ND ND AA002126 Hs.127799 Baculoviral IAP repeat-containing 3 BIRC3 0 0.15 3.2 0 -0.1 -1.1 0 -0.08 -0.7 NM_001165 0 330 1421392_a_at 0 0.067 0.3 0 2.28E-01 1.03E+00 Mm.2026 Birc3 1425223_at -0.048 -0.315 -2.86E-01 -1.86E+00 Mm.2026 Birc3 AA002126 Hs.127799 Baculoviral IAP repeat-containing 3 BIRC3 0 0.15 2.9 0 -0.05 -0.6 0 -0.06 -0.4 NM_001165 0 330 1421392_a_at 0 0.067 0.3 0 2.28E-01 1.03E+00 Mm.2026 Birc3 1425223_at -0.048 -0.315 -2.86E-01 -1.86E+00 Mm.2026 Birc3 AA004317 Hs.533308 "Protein phosphatase 2, regulatory subunit B (B56), delta isoform" PPP2R5D 0 0.07 1.4 0 0 0 0 0.01 0.2 NM_006245 0 5528 1450560_a_at 0 0.086 0.282 0 -4.54E-01 -1.48E+00 Mm.295009 Ppp2r5d AA004664 Data not found 0 0.01 0.2 0 -0.07 -1.2 0 -0.15 -1.5 ND Data not found AA004687 Data not found 0 -0.07 -0.8 0 -0.03 -0.5 0 0.11 1.4 ND Data not found AA004759 Hs.549080 "Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit" DPM1 0 -0.11 -2.1 -1 -0.14 -4.2 -1 -0.21 -4.2 NM_003859 0 8813 1420253_at 0 0.174 0.503 0 2.98E-01 8.63E-01 Mm.201322 Adnp 1423069_at 0.085 0.317 1.06E-01 3.98E-01 Mm.201322 Adnp 1449795_at -0.043 -0.289 -3.32E-02 -2.25E-01 Mm.201322 Adnp AA004823 Hs.517172 Death associated transcription factor 1 DATF1 0 -0.21 -1.9 0 0.03 0.4 0 -0.26 -2.8 NM_022105 0 11083 Data not found ND ND AA004823 Hs.517172 Death associated transcription factor 1 DATF1 0 -0.09 -1.2 0 0.05 0.3 0 -0.05 -0.2 NM_022105 0 11083 Data not found ND ND AA004835 Hs.153299 Dom-3 homolog Z (C. elegans) DOM3Z 0 -0.11 -1.1 0 0.02 0.3 0 0.14 2 NM_005510 0 1797 1423116_at -1 -0.401 -2.51 0 -1.35E-01 -8.44E-01 Mm.275309 Dom3z AA005153 Hs.478125 InaD-like (Drosophila) INADL 0 -0.07 -1 0 -0.02 -0.3 0 0 0 NM_005799 0 10207 Data not found ND ND AA005215 Hs.155342 "Protein kinase C, delta" PRKCD 0 -0.02 -0.3 0 0.03 0.7 0 0.09 1.5 NM_006254 0 5580 1422847_a_at -1 -0.087 -0.236 0 5.58E-02 1.51E-01 Mm.2314 Prkcd 1442256_at -0.675 -2.526 -2.61E-01 -9.78E-01 Mm.2314 Prkcd AA005219 Hs.148266 Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) GPD2 0 -0.19 -0.6 0 0.09 1.7 1 0.23 3.1 NM_000408 0 2820 1417434_at 0 -0.371 -1.56 -1 -9.83E-02 -4.13E-01 Mm.3711 Gpd2 1428323_at 0.051 0.207 -2.90E-01 -1.17E+00 Mm.3711 Gpd2 1452741_s_at -0.303 -1.911 -3.36E-01 -2.12E+00 Mm.3711 Gpd2 AA005219 Hs.148266 Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) GPD2 0 0.09 0.6 0 0.12 2.3 0 0.05 0.6 NM_000408 0 2820 1417434_at 0 -0.371 -1.56 -1 -9.83E-02 -4.13E-01 Mm.3711 Gpd2 1428323_at 0.051 0.207 -2.90E-01 -1.17E+00 Mm.3711 Gpd2 1452741_s_at -0.303 -1.911 -3.36E-01 -2.12E+00 Mm.3711 Gpd2 AA005382 Hs.277937 "Granzyme K (serine protease, granzyme 3; tryptase II)" GZMK 1 0.29 5.3 0 0.01 0.1 0 0.01 0.1 NM_002104 0 3003 1422280_at 0 0.097 0.639 0 -5.78E-02 -3.80E-01 Mm.56993 Gzmk AA007395 Hs.1219 "Alcohol dehydrogenase 4 (class II), pi polypeptide" ADH4 0 0.27 1.2 0 0 0 0 -0.01 -0.1 NM_000670 0 127 1422070_at 0 0.164 0.674 0 -1.63E-01 -6.69E-01 Mm.277198 Adh4 AA007419 Hs.386726 Regulator of G-protein signalling 4 RGS4 0 0 0 0 -0.02 -0.2 0 -0.13 -1.2 NM_005613 0 5999 Data not found ND ND AA007444 Hs.89583 "T-cell leukemia, homeobox 1" TLX1 -1 -0.7 -5.9 0 0.07 0.4 0 0.06 0.6 NM_005521 0 3195 1450526_at 0 -0.157 -0.793 0 -1.04E-01 -5.22E-01 Mm.103582 Tlx1 AA007444 Hs.89583 "T-cell leukemia, homeobox 1" TLX1 0 0.02 0.5 0 -0.03 -0.4 0 -0.17 -0.7 NM_005521 0 3195 1450526_at 0 -0.157 -0.793 0 -1.04E-01 -5.22E-01 Mm.103582 Tlx1 AA007560 Hs.444407 Paired immunoglobin-like type 2 receptor alpha PILRA 0 -0.08 -0.4 0 0.02 0.2 0 0.03 0.2 NM_178272 ND 29992 1427327_at 0 -0.221 -1.207 0 3.87E-02 2.11E-01 Mm.347593 Pilra AA007632 Hs.216226 Synaptogyrin 1 SYNGR1 0 -0.08 -0.4 0 -0.16 -2.1 0 0.13 1.1 NM_004711 1 9145 1419289_a_at 0 -1.231 -0.906 0 6.89E-02 5.07E-02 Mm.230301 Syngr1 1434661_at -0.204 -0.632 -1.43E-02 -4.43E-02 Mm.230301 Syngr1 1453772_at -0.298 -1.933 -2.37E-01 -1.54E+00 Mm.230301 Syngr1 AA007699 Hs.188456 "Phosphatidylinositol glycan, class C" PIGC 0 0.12 0.6 0 0 0 0 -0.15 -2.3 NM_153747 ND 5279 1424189_at 0 -0.362 -0.75 0 3.34E-01 6.93E-01 Mm.45106 Pigc 1424190_at -0.256 -1.441 7.81E-02 4.39E-01 Mm.45106 Pigc AA009484 Hs.110196 Chromosome 1 open reading frame 42 C1orf42 0 0.22 0.7 0 0.09 1 0 0.17 1.4 NM_019060 1 54544 1453092_at 0 -0.057 -0.295 0 -2.64E-01 -1.36E+00 Mm.35806 2300002G24Rik AA009609 Hs.549033 Fibroblast growth factor 7 (keratinocyte growth factor) FGF7 0 -0.09 -0.4 0 0.05 0.7 0 0.23 2.1 NM_002009 ND 2252 1422243_at 0 -0.294 -1.006 0 3.47E-01 1.19E+00 Mm.330557 Fgf7 1438405_at -0.018 -0.088 1.55E-01 7.56E-01 Mm.330557 Fgf7 AA009609 Hs.549033 Fibroblast growth factor 7 (keratinocyte growth factor) FGF7 0 0.04 0.5 0 0.08 0.6 0 0.03 0.1 NM_002009 ND 2252 1422243_at 0 -0.294 -1.006 0 3.47E-01 1.19E+00 Mm.330557 Fgf7 1438405_at -0.018 -0.088 1.55E-01 7.56E-01 Mm.330557 Fgf7 AA009738 Hs.22824 MYB binding protein (P160) 1a MYBBP1A 0 -0.01 -0.1 0 0.09 1.5 0 0.02 0.3 NM_014520 0 10514 1423430_at 0 -0.505 -1.656 -1 -8.25E-01 -2.71E+00 Mm.147946 Mybbp1a 1423431_a_at -0.504 -1.018 -4.68E-01 -9.45E-01 Mm.147946 Mybbp1a AA010065 Hs.83758 CDC28 protein kinase regulatory subunit 2 CKS2 0 0.02 0.4 0 -0.03 -0.7 -1 -0.4 -7 NM_001827 1 1164 1417457_at 0 0.15 0.503 0 1.13E-01 3.78E-01 Mm.222228 Cks2 1417458_s_at 0.128 0.33 1.78E-01 4.61E-01 Mm.222228 Cks2 AA010079 Hs.131431 Eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2 0 0.14 2.1 -1 -0.21 -3.8 0 0 0 NM_002759 0 5610 1422005_at 0 -0.269 -0.628 0 1.73E-01 4.05E-01 Mm.311918 Prkr 1422006_at -0.435 -1.298 -1.07E-01 -3.19E-01 Mm.311918 Prkr 1440866_at 0.156 0.983 1.20E-02 7.57E-02 Mm.311918 Prkr AA010079 Hs.131431 Eukaryotic translation initiation factor 2-alpha kinase 2 EIF2AK2 0 0.25 3.3 0 -0.06 -0.8 0 0 -0.1 NM_002759 0 5610 1422005_at 0 -0.269 -0.628 0 1.73E-01 4.05E-01 Mm.311918 Prkr 1422006_at -0.435 -1.298 -1.07E-01 -3.19E-01 Mm.311918 Prkr 1440866_at 0.156 0.983 1.20E-02 7.57E-02 Mm.311918 Prkr AA010192 Hs.160211 Thyroid hormone receptor associated protein 3 THRAP3 0 -0.02 -0.4 1 0.17 3.7 1 0.19 2.8 NM_005119 0 9967 1427408_a_at 0 -0.804 -1.415 0 -1.87E-01 -3.28E-01 Mm.236211 Thrap3 1452125_at 0.103 0.268 2.70E-01 7.05E-01 Mm.236211 Thrap3 1460545_at 0.225 1.08 -2.29E-01 -1.10E+00 Mm.236211 Thrap3 AA010352 Hs.288178 "Sjogren syndrome antigen A2 (60kDa, ribonucleoprotein autoantigen SS-A/Ro)" SSA2 0 -0.07 -1.4 0 0.09 1.1 0 0.17 1.2 NM_004600 0 6738 1423433_at 1 0.775 1.905 0 7.06E-01 1.73E+00 Mm.355161 Ssa2 1436533_at 0.77 1.76 6.25E-01 1.43E+00 Mm.355161 Ssa2 1436534_at 1.295 2.175 4.54E-01 7.63E-01 Mm.355161 Ssa2 1436535_at 0.707 1.402 6.78E-01 1.34E+00 Mm.355161 Ssa2 AA010400 Hs.434059 "Ets variant gene 4 (E1A enhancer binding protein, E1AF)" ETV4 0 0.04 0.5 0 0.02 0.2 0 -0.15 -1.5 NM_001986 0 2118 1423232_at 0 0.085 0.306 0 3.30E-02 1.19E-01 Mm.5025 Etv4 1443381_at -0.137 -0.271 4.81E-02 9.50E-02 Mm.5025 Etv4 AA010400 Hs.434059 "Ets variant gene 4 (E1A enhancer binding protein, E1AF)" ETV4 0 0.21 1.8 0 0.09 1.2 0 -0.11 -0.6 NM_001986 0 2118 1423232_at 0 0.085 0.306 0 3.30E-02 1.19E-01 Mm.5025 Etv4 1443381_at -0.137 -0.271 4.81E-02 9.50E-02 Mm.5025 Etv4 AA010492 Hs.35947 Methyl-CpG binding domain protein 4 MBD4 0 -0.06 -1.2 0 -0.02 -0.5 0 -0.01 -0.2 NM_003925 1 8930 1449490_at 0 -0.216 -0.681 0 -4.16E-02 -1.31E-01 Mm.259308 Mbd4 1457708_at -0.146 -0.232 2.18E-01 3.47E-01 Mm.259308 Mbd4 AA010503 Hs.464622 "N-ethylmaleimide-sensitive factor attachment protein, gamma" NAPG 0 0.03 0.5 0 0.02 0.5 0 -0.08 -1.1 NM_003826 ND 8774 1424069_at -1 0.279 0.671 0 2.15E-01 5.18E-01 Mm.292687 Napg 1424070_at -0.262 -0.979 -3.74E-02 -1.40E-01 Mm.292687 Napg 1443366_at -0.8 -2.905 1.25E-01 4.54E-01 Mm.292687 Napg AA010605 Hs.2899 4-hydroxyphenylpyruvate dioxygenase HPD 0 0.1 0.8 0 0.12 2.4 1 0.41 5.5 NM_002150 0 3242 1424618_at 0 0.211 1.092 0 6.20E-02 3.21E-01 Mm.6584 Hpd AA010609 Hs.295449 Parvalbumin PVALB 0 0.17 1.6 0 -0.05 -0.8 0 -0.09 -0.9 NM_002854 0 5816 1417653_at 0 0.256 0.813 0 1.57E-01 4.98E-01 Mm.2766 Pvalb AA011014 Hs.114762 "Retinol binding protein 3, interstitial" RBP3 0 -0.15 -0.8 0 0.02 0.2 0 0.03 0.2 NM_002900 0 5949 1425105_at 0 0.083 0.425 0 -2.94E-02 -1.50E-01 Mm.151562 Rbp3 1457855_at -0.034 -0.173 1.28E-01 6.53E-01 Mm.151562 Rbp3 AA011057 Data not found 0 0.28 3.2 0 -0.17 -1.5 0 -0.17 -1.1 ND Data not found AA011096 Hs.183109 Monoamine oxidase A MAOA 0 0.2 1.8 0 -0.04 -0.6 0 -0.29 -2.9 NM_000240 0 4128 1428667_at 0 0.238 1.061 0 2.33E-01 1.04E+00 Mm.21108 Maoa 1442676_at 0.086 0.369 -9.79E-02 -4.20E-01 Mm.21108 Maoa AA011215 Hs.28491 Spermidine/spermine N1-acetyltransferase SAT 0 -0.24 -3.5 0 -0.06 -0.7 0 -0.24 -1.7 NM_002970 0 6303 1420502_at 0 -0.137 -0.271 0 3.03E-03 6.00E-03 Mm.2734 Sat1 AA011320 Hs.550902 Transcribed locus 0 0.24 2.3 0 -0.25 -2.6 0 -0.18 -1.3 ND Data not found AA011347 Hs.432616 IGF-II mRNA-binding protein 3 IMP-3 0 0.03 0.3 -1 -0.28 -5.5 0 -0.1 -1.4 NM_006547 1 10643 1422610_s_at 0 0.173 0.337 0 4.49E-02 8.77E-02 Mm.281018 Igf2bp3 1422611_s_at 0.182 0.533 3.40E-01 9.93E-01 Mm.321068 2410003K15Rik 1433731_at 0.153 0.891 2.24E-01 1.30E+00 Mm.321068 2410003K15Rik 1433732_x_at 0.25 1.553 2.08E-01 1.29E+00 Mm.321068 2410003K15Rik 1450687_at 0.127 0.383 3.85E-01 1.16E+00 Mm.321068 2410003K15Rik 1453957_a_at -0.094 -0.391 -1.54E-01 -6.40E-01 Mm.281018 Igf2bp3 1459016_at 0.079 0.551 1.69E-02 1.17E-01 Mm.281018 Igf2bp3 AA011414 Hs.351593 "Fibrinogen, A alpha polypeptide" FGA 0 0.23 1.2 0 0.07 1.3 0 -0.09 -1.1 NM_000508 0 2243 1424279_at 1 0.952 2.631 0 -1.58E-01 -4.38E-01 Mm.88793 Fga AA011415 Hs.368588 Kell blood group KEL 0 -0.04 -0.4 0 -0.06 -0.9 0 -0.04 -0.5 NM_000420 0 3792 1449057_at 0 -1.238 -1.43 0 -2.98E-01 -3.45E-01 Mm.19958 Kel AA011446 Hs.141125 "Caspase 3, apoptosis-related cysteine protease" CASP3 0 -0.12 -2.3 -1 -0.24 -4.2 1 0.31 3.6 NM_004346 1 836 1426165_a_at 0 0.509 1.494 0 1.77E-01 5.19E-01 Mm.34405 Casp3 1430192_at 0.159 0.92 6.86E-02 3.97E-01 Mm.34405 Casp3 1449839_at 0.712 1.365 9.93E-02 1.90E-01 Mm.34405 Casp3 AA011446 Hs.141125 "Caspase 3, apoptosis-related cysteine protease" CASP3 0 -0.15 -1.4 0 -0.13 -1.7 0 -0.07 -0.7 NM_004346 1 836 1426165_a_at 0 0.509 1.494 0 1.77E-01 5.19E-01 Mm.34405 Casp3 1430192_at 0.159 0.92 6.86E-02 3.97E-01 Mm.34405 Casp3 1449839_at 0.712 1.365 9.93E-02 1.90E-01 Mm.34405 Casp3 AA011593 Hs.529285 "Solute carrier family 40 (iron-regulated transporter), member 1" SLC40A1 0 -0.16 -0.7 0 0.08 0.7 0 0.14 0.9 NM_014585 1 30061 1417061_at 0 0.342 1.012 -1 -7.92E-01 -2.35E+00 Mm.28756 Slc40a1 1447227_at 0.385 1.856 -2.90E-01 -1.40E+00 Mm.28756 Slc40a1 1448566_at -0.256 -0.663 -7.08E-01 -1.83E+00 Mm.28756 Slc40a1 AA011681 Hs.517357 DiGeorge syndrome critical region gene 2 DGCR2 0 0.08 0.7 0 -0.06 -0.5 0 -0.2 -1.3 NM_005137 1 9993 1435276_a_at 0 -0.291 -0.778 0 -4.41E-01 -1.18E+00 Mm.254515 Dgcr2 25784 Data not found ND ND 25786 Data not found ND ND AA012822 Hs.502688 Oxysterol binding protein OSBP 0 -0.04 -0.6 0 -0.02 -0.5 0 0.09 1.3 NM_002556 ND 5007 1460350_at 0 -0.22 -0.527 0 -5.99E-02 -1.43E-01 Mm.291279 Osbp AA012867 Hs.525330 ADP-ribosylation factor 6 ARF6 0 0.38 1.6 0 -0.06 -0.5 0 0.12 0.8 NM_001663 0 382 1418822_a_at 0 -0.172 -0.777 0 -4.02E-01 -1.82E+00 Mm.27308 Arf6 1418823_at -0.386 -0.724 -5.91E-01 -1.11E+00 Mm.27308 Arf6 1418824_at -0.132 -0.593 7.84E-03 3.54E-02 Mm.27308 Arf6 1434312_at -0.038 -0.125 -5.34E-01 -1.76E+00 Mm.27308 Arf6 AA012882 Data not found 0 -0.04 -0.4 0 -0.01 -0.1 1 0.19 3.3 ND Data not found AA012944 Hs.8867 "Cysteine-rich, angiogenic inducer, 61" CYR61 0 -0.3 -1.7 -1 -0.72 -13.8 -1 -0.87 -11.4 NM_001554 1 3491 1416039_x_at -1 -0.035 -0.079 0 -1.65E-01 -3.70E-01 Mm.1231 Cyr61 1438133_a_at 0.012 0.021 -3.72E-01 -6.33E-01 Mm.1231 Cyr61 1442340_x_at -1.446 -6.834 1.30E-01 6.13E-01 Mm.1231 Cyr61 1457823_at -1.491 -5.925 1.05E-01 4.16E-01 Mm.1231 Cyr61 AA013095 Hs.157818 "Potassium voltage-gated channel, shaker-related subfamily, beta member 1" KCNAB1 0 0.03 0.3 0 0 0.1 0 -0.06 -0.8 NM_003471 1 7881 1448468_a_at 1 0.547 2.48 0 2.93E-01 1.33E+00 Mm.316402 Kcnab1 1454043_a_at 0.276 1.836 -1.22E-01 -8.11E-01 Mm.316402 Kcnab1 AA013172 Hs.368325 Suppressor of Ty 3 homolog (S. cerevisiae) SUPT3H 0 0.1 1.5 0 0 0 0 0.02 0.2 NM_003599 0 8464 1434963_at 0 -0.354 -1.524 0 1.07E-01 4.63E-01 Mm.129257 Supt3h 1458692_at 0.009 0.048 -1.81E-01 -9.89E-01 Mm.129257 Supt3h AA013268 Hs.432898 Ribosomal protein L4 RPL4 0 0.18 0.7 0 -0.01 -0.1 0 0.09 1.1 NM_000968 1 6124 1425183_a_at 0 0.017 0.055 0 1.13E-01 3.77E-01 Mm.280083 Rpl4 9175 1430137_at 1 0.073 0.196 0 1.98E-01 5.36E-01 Mm.353050 1300002E11Rik 1440749_at 0.572 1.766 3.52E-01 1.08E+00 Mm.353050 1300002E11Rik 1447699_at 0.348 2.177 -1.38E-03 -8.65E-03 Mm.353050 1300002E11Rik AA015621 Hs.500067 "Protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" PPP3CB 0 0.01 0.1 0 -0.01 -0.2 0 0.09 0.9 NM_021132 0 5532 1427468_at 1 0.285 1.378 0 1.65E-01 7.96E-01 Mm.274432 Ppp3cb 1428473_at 0.532 1.594 1.97E-01 5.89E-01 Mm.274432 Ppp3cb 1428474_at 0.177 0.761 7.76E-02 3.34E-01 Mm.274432 Ppp3cb 1433835_at 0.585 2.841 -1.12E-01 -5.46E-01 Mm.274432 Ppp3cb 1446149_at 0.267 1.147 8.19E-02 3.52E-01 Mm.274432 Ppp3cb 1459378_at -0.136 -0.795 -9.33E-02 -5.44E-01 Mm.274432 Ppp3cb AA015892 Hs.355867 Methionine-tRNA synthetase MARS 0 -0.16 -1.4 -1 -0.23 -4.3 0 -0.03 -0.4 NM_004990 1 4141 1455951_at -1 -0.486 -2.223 0 -2.13E-01 -9.73E-01 Mm.28173 Mars AA015914 Hs.483635 Fibroblast growth factor 1 (acidic) FGF1 0 0.1 0.8 0 0.18 2.1 0 0.03 0.2 NM_000800 1 2246 1423136_at 0 0.042 0.248 0 2.69E-01 1.59E+00 Mm.241282 Fgf1 1441042_at -0.058 -0.272 -8.95E-02 -4.17E-01 Mm.241282 Fgf1 1447396_at 0.001 0.005 -1.32E-02 -8.86E-02 Mm.241282 Fgf1 1450869_at 0.105 0.616 -1.21E-01 -7.13E-01 Mm.241282 Fgf1 1459177_at -0.007 -0.035 1.71E-01 8.82E-01 Mm.241282 Fgf1 AA016254 Hs.367437 Hypothetical protein MGC33948 MGC33948 0 0.01 0.1 1 0.12 2.8 1 0.15 2.7 NM_152587 ND 160140 1429824_at 0 -0.066 -0.32 0 -4.64E-02 -2.27E-01 Mm.26078 4930550C14Rik AA016290 Hs.188553 Retinoblastoma binding protein 6 RBBP6 0 -0.25 -3 0 0.13 2.5 0 0.06 0.8 NM_006910 1 5930 1425114_at 0 0.139 0.576 0 -1.39E-01 -5.75E-01 Mm.127823 Rbbp6 1425115_at 0.185 0.858 3.36E-01 1.55E+00 Mm.127823 Rbbp6 1425421_at 0.119 0.271 6.66E-02 1.52E-01 Mm.127823 Rbbp6 1426487_a_at -0.085 -0.166 3.81E-01 7.44E-01 Mm.127823 Rbbp6 1453611_at 0.044 0.265 -4.05E-02 -2.42E-01 Mm.127823 Rbbp6 AA017043 Hs.528299 "HIV-1 Tat interacting protein, 60kDa" HTATIP -1 -0.23 -4.3 0 -0.06 -1.3 0 -0.12 -1.8 NM_006388 0 10524 1433980_at 0 0.057 0.167 0 -2.71E-01 -7.97E-01 Mm.228930 Htatip 1433981_s_at -0.1 -0.367 -1.89E-01 -6.96E-01 Mm.228930 Htatip AA017125 Hs.485195 Sortilin 1 SORT1 0 0.2 1.5 0 0.1 1.1 0 0.02 0.2 NM_002959 1 6272 1423362_at 1 0.884 1.708 0 5.72E-02 1.11E-01 Mm.157119 Sort1 1423363_at 0.123 0.704 9.05E-02 5.20E-01 Mm.157119 Sort1 1450955_s_at 0.618 2.921 1.45E-02 6.83E-02 Mm.157119 Sort1 AA017132 Hs.250687 "Transient receptor potential cation channel, subfamily C, member 1" TRPC1 0 0.1 0.8 0 0 0 -1 -0.43 -4.4 NM_003304 0 7220 1421095_a_at 0 -0.087 -0.536 0 -5.88E-02 -3.63E-01 Mm.149633 Trpc1 1421096_at 0.248 0.752 1.91E-01 5.81E-01 Mm.149633 Trpc1 AA017175 Hs.500409 Glutamate dehydrogenase 1 GLUD1 0 0.06 0.8 0 0.06 1.3 0 -0.12 -1.8 NM_005271 1 2746 1416209_at 0 -0.256 -0.576 0 1.06E-01 2.39E-01 Mm.10600 Glud1 1448253_at 0.167 0.478 1.45E-01 4.16E-01 Mm.10600 Glud1 AA017200 Hs.518773 "Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)" UBE2D3 0 -0.06 -0.7 0 -0.06 -1.7 0 -0.06 -1.2 NM_003340 0 7323 1423112_at 0 0.631 1.569 0 1.36E-01 3.37E-01 Mm.256765 Nfkb1 1423113_a_at 0.198 0.433 2.02E-01 4.41E-01 Mm.256765 Nfkb1 1423114_at 0.893 1.774 2.30E-01 4.58E-01 Mm.256765 Nfkb1 1427705_a_at 0.835 1.948 -1.07E-01 -2.50E-01 Mm.256765 Nfkb1 1442949_at -0.057 -0.34 6.19E-02 3.67E-01 Mm.256765 Nfkb1 1450858_a_at 0.594 1.636 4.53E-02 1.25E-01 Mm.256765 Nfkb1 1450859_s_at 0.642 1.523 3.30E-01 7.83E-01 Mm.256765 Nfkb1 1455479_a_at -0.019 -0.043 3.20E-02 7.30E-02 Mm.256765 Nfkb1 1455480_s_at 0.226 0.308 6.32E-02 8.60E-02 Mm.256765 Nfkb1 AA017379 Hs.203637 Plastin 1 (I isoform) PLS1 0 0.05 0.3 0 0.08 0.8 0 -0.08 -0.6 NM_002670 ND 5357 1460406_at 1 0.656 3.819 0 -2.93E-01 -1.70E+00 Mm.11869 AI427122 AA017383 Hs.122523 Staphylococcal nuclease domain containing 1 SND1 0 0.01 0.1 0 0.1 2.1 0 0.11 1.6 NM_014390 1 27044 1416038_at -1 -0.621 -1.227 0 -3.63E-01 -7.17E-01 Mm.29827 AL033314 1437036_at -0.09 -0.498 1.33E-01 7.34E-01 Mm.29827 AL033314 1437037_x_at -0.24 -1.05 -1.08E-01 -4.72E-01 Mm.29827 AL033314 1441067_at -0.032 -0.182 2.34E-01 1.33E+00 Mm.29827 AL033314 1441244_at 0.009 0.053 4.63E-02 2.70E-01 Mm.29827 AL033314 1442910_at 0.162 0.767 -1.53E-01 -7.22E-01 Mm.29827 AL033314 1444538_at -0.666 -3.127 1.07E-01 5.01E-01 Mm.29827 AL033314 AA017544 Hs.75256 Regulator of G-protein signalling 1 RGS1 1 0.65 12 0 0.02 0.2 0 -0.18 -1.3 NM_002922 1 5996 1417601_at 0 0.013 0.072 0 -1.44E-01 -8.14E-01 Mm.103701 Rgs1 AA018182 Hs.202354 "Deiodinase, iodothyronine, type II" DIO2 0 -0.17 -1.3 0 -0.12 -1 0 0.04 0.2 NM_000793 0 1734 1418937_at 0 0.008 0.045 1 4.81E-01 2.62E+00 Mm.21389 Dio2 1418938_at 0.144 0.547 2.52E-01 9.53E-01 Mm.21389 Dio2 1426081_a_at 0.197 0.494 3.67E-02 9.17E-02 Mm.21389 Dio2 AA018214 Hs.60843 "Potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)" KCNA1 0 0.27 3.2 0 0.02 0.3 0 0.18 1.8 NM_000217 0 3736 1437230_at 0 -0.087 -0.548 0 2.42E-01 1.52E+00 Mm.40424 Kcna1 1442413_at 0.192 0.972 5.31E-03 2.69E-02 Mm.40424 Kcna1 1455785_at 0.097 0.478 6.64E-02 3.28E-01 Mm.40424 Kcna1 AA018276 Hs.445265 LIM homeobox 2 LHX2 0 -0.2 -1 0 -0.01 -0.1 0 0.07 0.8 NM_004789 1 9355 1418317_at 0 -0.158 -0.896 0 -9.15E-02 -5.20E-01 Mm.142856 Lhx2 AA018449 Hs.303669 Hypothetical protein MGC26694 MGC26694 0 0.18 1.6 0 0.05 0.8 0 -0.03 -0.3 ND 284439 1443637_at 0 -0.17 -1.03 0 -1.10E-01 -6.67E-01 Mm.185413 2900084M01Rik AA018457 Hs.420036 "Glutamate decarboxylase 1 (brain, 67kDa)" GAD1 0 -0.02 -0.1 0 -0.06 -0.7 0 -0.06 -0.4 NM_000817 0 2571 1416561_at 0 -0.762 -1.074 0 3.93E-01 5.55E-01 Mm.272120 Gad1 1416562_at -0.14 -0.804 1.88E-01 1.08E+00 Mm.272120 Gad1 AA018572 Hs.118555 "Fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)" FSCN2 0 0 0 0 -0.06 -0.6 0 -0.1 -0.7 NM_012418 0 25794 1440605_at 0 0.338 1.028 0 -1.87E-01 -5.69E-01 Mm.134230 Fscn2 AA018591 Hs.503178 "Spectrin, beta, non-erythrocytic 1" SPTBN1 0 -0.04 -0.8 0 0.07 1.6 1 0.15 2.4 NM_003128 1 6711 1419255_at 0 -0.162 -0.572 0 3.70E-01 1.31E+00 Mm.123110 Spnb2 1419256_at -0.509 -0.926 -1.54E-01 -2.79E-01 Mm.123110 Spnb2 1444089_at -0.217 -1.094 1.72E-01 8.67E-01 Mm.123110 Spnb2 1446545_at 0.15 0.993 -1.15E-01 -7.58E-01 Mm.123110 Spnb2 1451830_a_at -0.023 -0.094 -1.52E-02 -6.18E-02 Mm.123110 Spnb2 1452143_at 0.169 0.723 6.72E-02 2.87E-01 Mm.123110 Spnb2 AA018683 Hs.505 "ISL1 transcription factor, LIM/homeodomain, (islet-1)" ISL1 0 0.04 0.4 0 0.17 1.7 0 -0.02 -0.1 NM_002202 0 3670 1422720_at 1 1.495 2.111 0 5.81E-01 8.20E-01 Mm.42242 Isl1 1444129_at 0.043 0.286 7.66E-02 5.05E-01 Mm.42242 Isl1 1450723_at 2.334 2.352 2.81E-01 2.83E-01 Mm.42242 Isl1 AA018866 Hs.235782 "Solute carrier organic anion transporter family, member 4A1" SLCO4A1 0 -0.06 -0.5 0 -0.05 -0.8 0 0.02 0.2 NM_016354 1 28231 1438160_x_at -1 -1.894 -2.556 0 -4.69E-02 -6.34E-02 Mm.133687 Slco4a1 1455803_at -1.022 -2.41 -4.12E-03