Identification of biological processes regulated by the transcription
factor RUNX1: implication for leukemia and thrombocytopenia
development
Table I
Acc UGCluster Name Symbol FPD FPD M FPD t CBF CBF M CBF t TELRUNX1 TELRUNX1 M TELRUNX1 t Refseq CUREOS Human Gene ID mouse Affymetrix probes E8.5 M 8.5 t 8.5 E12 M 12 t 12 mouse Unigene Mouse Gene Symbol AA001219 Hs.527973 Suppressor of cytokine signaling 3 SOCS3 0 -0.02 -0.4 0 0.01 0.2 0 -0.1 -1.4 NM_003955 1 9021 1416576_at -1 -0.3 -1.193 0 2.74E-01 1.09E+00 Mm.3468 Socs3 1455899_x_at -1.715 -2.492 -2.25E-01 -3.28E-01 Mm.3468 Socs3 1456212_x_at -1.397 -1.784 -1.10E-01 -1.41E-01 Mm.3468 Socs3 AA001376 Hs.157883 Zinc finger protein 187 ZNF187 0 0.04 0.5 0 0.06 0.9 0 0 0 NM_152736 ND 7741 1457285_at 0 0.021 0.037 0 4.06E-01 7.16E-01 Mm.235360 AA001403 Hs.132642 "Zinc metallopeptidase (STE24 homolog, yeast)" ZMPSTE24 0 0.09 1.3 0 0.06 1.4 1 0.21 3.2 NM_005857 0 10269 1427923_at 0 0.088 0.282 0 5.09E-01 1.63E+00 Mm.34399 Zmpste24 AA001432 Hs.436367 "Laminin, alpha 3" LAMA3 0 0.16 1.4 0 -0.02 -0.4 0 -0.09 -1.4 NM_000227 0 3909 1427512_a_at 0 0.23 0.854 0 -1.76E-01 -6.53E-01 Mm.42012 Lama3 1444860_at -0.077 -0.367 1.40E-02 6.65E-02 Mm.42012 Lama3 AA001444 Hs.526754 "Meis1, myeloid ecotropic viral integration site 1 homolog (mouse)" MEIS1 0 0.13 1.1 1 0.2 3.9 1 0.18 2.6 NM_002398 1 4211 Data not found ND ND AA001449 Hs.371249 "Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" PTN 0 -0.03 -0.3 0 0.08 0.8 0 0.14 0.9 NM_002825 1 5764 1416211_a_at 0 1.168 0.926 0 3.72E-01 2.95E-01 Mm.279690 Ptn 1443173_at 0.094 0.244 3.27E-01 8.53E-01 Mm.279690 Ptn 1443809_at -0.057 -0.316 2.63E-02 1.47E-01 Mm.279690 Ptn 1448254_at 2.288 1.509 2.09E-01 1.38E-01 Mm.279690 Ptn AA001449 Hs.371249 "Pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1)" PTN 0 0.18 2.4 0 0.01 0.1 0 -0.09 -0.9 NM_002825 1 5764 1416211_a_at 0 1.168 0.926 0 3.72E-01 2.95E-01 Mm.279690 Ptn 1443173_at 0.094 0.244 3.27E-01 8.53E-01 Mm.279690 Ptn 1443809_at -0.057 -0.316 2.63E-02 1.47E-01 Mm.279690 Ptn 1448254_at 2.288 1.509 2.09E-01 1.38E-01 Mm.279690 Ptn AA001614 Data not found 0 0.22 2.7 0 0.04 0.6 0 0.21 2 ND Data not found AA001745 Hs.445803 DC2 protein DC2 -1 -0.28 -5.4 0 0.06 2.1 0 0.05 1.1 NM_021227 0 58505 1429898_at 0 -0.276 -0.869 0 -3.44E-02 -1.08E-01 Mm.300697 2310008M10Rik 1449139_at 0.442 1.003 3.32E-01 7.53E-01 Mm.300697 2310008M10Rik AA001749 Hs.472437 "Microtubule-associated protein, RP/EB family, member 1" MAPRE1 0 0.14 2.3 -1 -0.16 -3.4 0 -0.08 -1 NM_012325 1 22919 1422764_at 1 0.111 0.334 0 2.55E-01 7.67E-01 Mm.143877 Mapre1 1422765_at 0.835 4.955 2.49E-01 1.48E+00 Mm.143877 Mapre1 1428819_at 0.426 0.84 7.31E-02 1.44E-01 Mm.143877 Mapre1 1428820_at -0.189 -0.57 -1.53E-01 -4.60E-01 Mm.143877 Mapre1 1450740_a_at 0.25 0.597 2.89E-01 6.90E-01 Mm.143877 Mapre1 AA001897 Hs.119825 "Spectrin, alpha, erythrocytic 1 (elliptocytosis 2)" SPTA1 0 0.07 0.7 1 0.21 4.1 0 -0.13 -1.6 NM_003126 0 6708 1421277_at 0 -1.176 -1.64 0 -8.59E-02 -1.20E-01 Mm.200611 Spna1 1421278_s_at -1.343 -1.699 -1.37E-01 -1.74E-01 Mm.200611 Spna1 AA002086 Hs.1311 "CD1C antigen, c polypeptide" CD1C 0 0.29 3.4 0 -0.01 -0.1 0 -0.06 -0.7 NM_001765 ND 911 Data not found ND ND AA002126 Hs.127799 Baculoviral IAP repeat-containing 3 BIRC3 0 0.15 3.2 0 -0.1 -1.1 0 -0.08 -0.7 NM_001165 0 330 1421392_a_at 0 0.067 0.3 0 2.28E-01 1.03E+00 Mm.2026 Birc3 1425223_at -0.048 -0.315 -2.86E-01 -1.86E+00 Mm.2026 Birc3 AA002126 Hs.127799 Baculoviral IAP repeat-containing 3 BIRC3 0 0.15 2.9 0 -0.05 -0.6 0 -0.06 -0.4 NM_001165 0 330 1421392_a_at 0 0.067 0.3 0 2.28E-01 1.03E+00 Mm.2026 Birc3 1425223_at -0.048 -0.315 -2.86E-01 -1.86E+00 Mm.2026 Birc3 AA004317 Hs.533308 "Protein phosphatase 2, regulatory subunit B (B56), delta isoform" PPP2R5D 0 0.07 1.4 0 0 0 0 0.01 0.2 NM_006245 0 5528 1450560_a_at 0 0.086 0.282 0 -4.54E-01 -1.48E+00 Mm.295009 Ppp2r5d AA004664 Data not found 0 0.01 0.2 0 -0.07 -1.2 0 -0.15 -1.5 ND Data not found AA004687 Data not found 0 -0.07 -0.8 0 -0.03 -0.5 0 0.11 1.4 ND Data not found AA004759 Hs.549080 "Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit" DPM1 0 -0.11 -2.1 -1 -0.14 -4.2 -1 -0.21 -4.2 NM_003859 0 8813 1420253_at 0 0.174 0.503 0 2.98E-01 8.63E-01 Mm.201322 Adnp 1423069_at 0.085 0.317 1.06E-01 3.98E-01 Mm.201322 Adnp 1449795_at -0.043 -0.289 -3.32E-02 -2.25E-01 Mm.201322 Adnp AA004823 Hs.517172 Death associated transcription factor 1 DATF1 0 -0.21 -1.9 0 0.03 0.4 0 -0.26 -2.8 NM_022105 0 11083 Data not found ND ND AA004823 Hs.517172 Death associated transcription factor 1 DATF1 0 -0.09 -1.2 0 0.05 0.3 0 -0.05 -0.2 NM_022105 0 11083 Data not found ND ND AA004835 Hs.153299 Dom-3 homolog Z (C. elegans) DOM3Z 0 -0.11 -1.1 0 0.02 0.3 0 0.14 2 NM_005510 0 1797 1423116_at -1 -0.401 -2.51 0 -1.35E-01 -8.44E-01 Mm.275309 Dom3z AA005153 Hs.478125 InaD-like (Drosophila) INADL 0 -0.07 -1 0 -0.02 -0.3 0 0 0 NM_005799 0 10207 Data not found ND ND AA005215 Hs.155342 "Protein kinase C, delta" PRKCD 0 -0.02 -0.3 0 0.03 0.7 0 0.09 1.5 NM_006254 0 5580 1422847_a_at -1 -0.087 -0.236 0 5.58E-02 1.51E-01 Mm.2314 Prkcd 1442256_at -0.675 -2.526 -2.61E-01 -9.78E-01 Mm.2314 Prkcd AA005219 Hs.148266 Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) GPD2 0 -0.19 -0.6 0 0.09 1.7 1 0.23 3.1 NM_000408 0 2820 1417434_at 0 -0.371 -1.56 -1 -9.83E-02 -4.13E-01 Mm.3711 Gpd2 1428323_at 0.051 0.207 -2.90E-01 -1.17E+00 Mm.3711 Gpd2 1452741_s_at -0.303 -1.911 -3.36E-01 -2.12E+00 Mm.3711 Gpd2 AA005219 Hs.148266 Glycerol-3-phosphate dehydrogenase 2 (mitochondrial) GPD2 0 0.09 0.6 0 0.12 2.3 0 0.05 0.6 NM_000408 0 2820 1417434_at 0 -0.371 -1.56 -1 -9.83E-02 -4.13E-01 Mm.3711 Gpd2 1428323_at 0.051 0.207 -2.90E-01 -1.17E+00 Mm.3711 Gpd2 1452741_s_at -0.303 -1.911 -3.36E-01 -2.12E+00 Mm.3711 Gpd2 AA005382 Hs.277937 "Granzyme K (serine protease, granzyme 3; tryptase II)" GZMK 1 0.29 5.3 0 0.01 0.1 0 0.01 0.1 NM_002104 0 3003 1422280_at 0 0.097 0.639 0 -5.78E-02 -3.80E-01 Mm.56993 Gzmk AA007395 Hs.1219 "Alcohol dehydrogenase 4 (class II), pi polypeptide" ADH4 0 0.27 1.2</